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KMID : 0363819950290030332
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Korean Journal of Nuclear Medicine
1995 Volume.29 No. 3 p.332 ~ p.342
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Radioimmunotherapy of Nude Mice Bearing Human Colon Carcinoma with I-131 Labeled Anti-carcinoembryonic Antigen Monoclonal Antibody
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김병태
이경한/김상은/최용/지대윤/정준기/이명철/고창순/정홍근
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Abstract
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This study was designed to evaluate the effects of various factors on the therapeutic effect of the I-131 labeled anti-carcinoembryonic antigen monoclonal antibody(anti-CEA antibody). Tetrazolium-based colorimetric assay (MTT) was used to compare
in
vitro cytotoxicity of 3 Korean colon cancer cell lines (SNU-C2A, SU-C4, SNU-C5) for selection of proper 2 cell lines in this study. The changes of the size of tumor which was xenografted to nude mice(balb/c nu/nu) were compared in 4 groups (group
treated I-131 labeled anti-CEA antibody, group treated with non-radiolabeled anti-CEA antibody, group treated with I-131 labeled anti-human chorionic gonadotropin monoclonal antibody (anti-hCG antibody as nonspecific antibody, and group injected
with
normal saline as a control). Immunohistochemical staining and in vivo autoradiography were performed after excision of the xenografted tumor. The results were as below mentioned.
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KEYWORD
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